Endocrine Abstracts

Neonatal autoimmune hyperthyroidism is rare but potentially fatal condition. It occurs in 1-5% of infants born to pregnant mothers with Graves’ disease (GD). We present a case of transient neonatal thyrotoxicosis born to pregnant women with GD and high TSH Receptor antibodies. 42 years pregnant lady was referred to Antenatal Endocrine clinic at Walsall Manor Hospital in 15th week of pregnancy with symptoms of Thyrotoxicosis. She has GD and was taking Propylthio...

Respiratory muscle weakness and diaphragmatic failure is a rare presentation of hypercortisolism. We report a case of Cushing’s syndrome in a 60-year-old female with history of rheumatoid arthritis, biliary cirrhosis and hypothyroidism. She presented to the Respiratory Physicians with progressive worsening of shortness of breath. Clinical assessment excluded infective pathology, cardiac failure or asthma. Pulmonary function tests (PFT) showed re...

Respiratory muscle weakness and diaphragmatic failure is a rare presentation of hypercortisolism. We report a case of Cushing’s syndrome in a 60-year-old female with history of rheumatoid arthritis, biliary cirrhosis and hypothyroidism. She presented to the Respiratory Physicians with progressive worsening of shortness of breath. Clinical assessment excluded infective pathology, cardiac failure or asthma. Pulmonary function tests (PFT) showed re...

Introduction: 3-β-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in decreased production of all three groups of adrenal steroids, which include mineralocorticoids, glucocorticoids, and sex steroids.Case presentation: An infant was born with ambiguous genitalia in 1975 to a conservative Muslim family and was registered as male. The child was hospitalised with addisonian crisis on the el...

Background: A minimally invasive approach to primary hyperparathyroidism (PHPT) is equivalent to bilateral exploration when intraoperative parathyroid hormone (iPTH) monitoring is used. We have recently established an iPTH service jointly with Surgical and Clinical Chemistry teams and the aim of the study was to evaluate our initial results with its use.Patients and methods: We collected data from 18 operations for PHPT from October 2015, including one r...

Background: Although, the diagnostic accuracy of magnetic resonance imaging (MRI) has increased in recent years, it may fail to detect secretory adenoma in a few patients with GH excess. Managing such patients with acromegaly can be challenging. We present a case where 11C-methionine PET/CT co-registered with SPGR/volume MRI proved to be helpful in identifying GH secreting pituitary adenoma.Case history: A 42-year-old male was referred by surg...